Recombinant PAL/PilE/FlaA DNA vaccine provides protective immunity against Legionella pneumophila in BALB/c mice
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چکیده
منابع مشابه
A live avirulent mutant Legionella pneumophila vaccine induces protective immunity against lethal aerosol challenge.
We have examined the capacity of a live avirulent mutant form of the intracellular bacterial pathogen Legionella pneumophila to induce immune responses and protective immunity in guinea pigs. The mutant L. pneumophila is nonlethal to guinea pigs and does not revert to virulence with passage through guinea pigs. In contrast, exposure of guinea pigs to aerosols containing wild-type L. pneumophila...
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larities. A comparison between the TPqnrS-1a-associated QnrS1 protein and the 218-amino-acid proteins from Vibrio splendidus (accession no. EAP95542) and Vibrio spp. (accession no. EAQ55748)—the latter two considered as a natural reservoir of qnrS genes—revealed 83% and 82% amino acid identity, respectively, and 91% amino acid similarity. Previous studies revealed that the qnrS1 gene is often l...
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Peripheral T-cell tolerance toward human carcinoembryonic self-antigen (CEA) was broken in CEA-transgenic C57BL/6J mice by an oral CEA-based DNA vaccine. This vaccine, delivered by the live, attenuated AroA- strain of Salmonella typhimurium (SL7207), induced tumor-protective immunity mediated by MHC class I-restricted CD8+ T cells. Activation of these T cells was indicated by increased secretio...
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ژورنال
عنوان ژورنال: BMC Biotechnology
سال: 2020
ISSN: 1472-6750
DOI: 10.1186/s12896-020-00620-3